関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Bromo-methoxy-chroman | HCID 20193557 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Diisopropyl Ether | HCID 7914 | — |
| 生成物 | 8-Methoxychromane-6-carbaldehyde | HCID 12831983 | 51% |
反応手順
The procedure is as according to the method described for preparation III, but maintaining the temperature at -50° C. From 186 g (7.7×10-1M) of bromo-methoxy-chroman Ib2 in 500 cm3 of anhydrous ether and 7.7×10-1M of n-butyllithium in 650 cm3 of anhydrous ether, and after addition of 78 g (1.1 M) of N,N-dimethylformamide in 200 cm3 of anhydrous ether and recrystallisation in isopropyl ether, 75 g (yield=51%) of expected compound are isolated. m.p.=81° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04436915 |
|---|
| 出典データセット | uspto-grants-1984_03 |
|---|
| ORD ID | ord-f86e1d0a8a474c68a8f22ae9ab89240b |
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| 出典メモ | uspto-grants-1984_03 |
|---|
