Phosgene → 3-(3-Phenylpropyl)phenyl isocyanate

HRID 1903653

反応式

HRID 1903653 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=2)[NH2:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17](Cl)(Cl)=[O:18]>C1(C)C=CC=CC=1>[C:1]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]([N:13]=[C:17]=[O:18])[CH:14]=[CH:15][CH:16]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 6371PhosgeneHCID 4273073-(3-Phenylpropyl)aniline

生成物 1

HCID 127905743-(3-Phenylpropyl)phenyl isocyanate収率 89%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a solution of 3-(3-phenylpropyl)aniline (11.6 g) in 100 ml of toluene was dropwise added a solution of phosgene (20 g) in 100 ml of toluene at 10°-20° C. The resultant mixture was gradually heated and, after refluxed for 30 minutes, allowed to cool to room temperature. The solvent was removed under reduced pressure, and the residue was distilled under reduced pressure to give 11.6 g of 3-(3-phenylpropyl)phenyl isocyanate (yield, 89%). B.P. 121°-125° C./0.2 mmHg.

後処理

  1. temperatureafter refluxed for 30 minutes
  2. customThe solvent was removed under reduced pressure
  3. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-2b1085577a094030a811874d9fb02bcd
出典データセット
uspto-grants-1984_03
特許番号
US04437880

関連ノート

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