Hydrazine → 5-Chloro-6-hydrazinyl-3-nitropyrazin-2-amine
反応式
[NH2:1][NH2:2].[Cl:3][C:4]1[N:5]=[C:6]([N+:12]([O-:14])=[O:13])[C:7]([NH2:11])=[N:8][C:9]=1Cl>C(O)C>[Cl:3][C:4]1[N:5]=[C:6]([N+:12]([O-:14])=[O:13])[C:7]([NH2:11])=[N:8][C:9]=1[NH:1][NH2:2]参加物
4
実験手順
To 300 ml of ethanol was added 7.4 g (0.22 mole) of a 95% hydrazine solution. This solution was cooled to 10° and with stirring 20.9 g (0.1 mole) of 5,6-dichloro-3-nitropyrazinamine (l) was added portionwise. A dark precipitate formed immediately and the suspension was stirred for 1 hour at room temperature. The mixture was filtered and the resulting solid washed with ethanol, water, ethyl acetate, ethanol and air dried to afford 18.0 g (88%) of the desired hydrazine as a brown solid, m.p. 220°; ms:m/e 205. This solid was treated with acetone to form the isopropylidene derivative, m.p. 245°-246° (dec.).
後処理
- temperatureThis solution was cooled to 10°
- additionwas added portionwise
- customA dark precipitate formed immediately
- filtrationThe mixture was filtered
- washthe resulting solid washed with ethanol, water, ethyl acetate, ethanol and air
- customdried
出典と根拠
- ORDレコード
- ord-aa7e1ebf2c7d46ec951c507123966cdb
- 出典データセット
- uspto-grants-1984_03
- 特許番号
- US04438266
反応ノート
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