Hydrochloric Acid → H-(D)Ala-Gly-OBzl.hydrochloride

HRID 1903866ノート

反応式

HRID 1903866 の反応式
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:5])[CH3:3].[ClH:25].CCOCC>O1CCOCC1>[NH2:1][C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:5])[CH3:3].[ClH:25]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15567200Boc-(D)Ala-Gly-OBzl

生成物 1

HCID 131712174H-(D)Ala-Gly-OBzl.hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3.4 g of Boc-(D)Ala-Gly-OBzl are dissolved in 50 ml of dioxane containing HCl and left to stand for one hour. The volume of the solution is reduced under vacuum and an excess of ether added. The precipitated salt is filtered off, dried and used as such for the coupling reaction.

後処理

  1. waitleft
  2. filtrationThe precipitated salt is filtered off
  3. customdried
  4. customsuch for the coupling reaction

出典と根拠

ORDレコード
ord-9f20d9343e204aba90facb8abb9f7130
出典データセット
uspto-grants-1984_03
特許番号
US04438103

反応ノート

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