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Methanol → 4-Dimethylaminomethyl-2-hydroxymethylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Ammonium Persulfate | HCID 62648 | — |
| 反応物 | 4-pyridinemethanamine, N,N-dimethyl- | HCID 264946 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Dimethylaminomethyl-2-hydroxymethylpyridine | HCID 13292601 | — |
反応手順
Ammonium persulphate (102.7 g) in water (200 ml) was added over 40 minutes to a refluxing solution of 4-dimethylaminomethylpyridine (40.86 g), methanol (450 ml), water (210 ml) and concentrated sulphuric acid (30 ml). The resulting solution was refluxed for 2 hours, water (300 ml) was added and the methanol was distilled off. The cooled solution was basified and extracted with chloroform to give 4-dimethylaminomethyl-2-hydroxymethylpyridine (19.65 g) b.p. 92°-120°/0.06 mm Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04439609 |
| 出典データセット | uspto-grants-1984_03 |
| ORD ID | ord-c7eefca3e0a14bd684887e664777da8b |
| 出典メモ | uspto-grants-1984_03 |