Phenyl isocyanate → N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine

HRID 1904634

反応式

HRID 1904634 の反応式
[SH:1][CH2:2][CH:3]([CH3:16])[C:4]([N:6]([CH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH2:7][C:8]([OH:10])=[O:9])=[O:5].[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)Cl.CCOCC>[C:17]1([NH:23][C:24]([S:1][CH2:2][CH:3]([CH3:16])[C:4]([N:6]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:7][C:8]([OH:10])=[O:9])=[O:5])=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 2

HCID 7672Phenyl isocyanateHCID 13469595(S)-[Cyclopentyl-(3-mercapto-2-methyl-propionyl)-amino]-acetic acid

生成物 1

HCID 13469596N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4.9 g (0.02M) of N-(3-mercapto-2-methyl propanoyl)-N-cyclopentyl glycine and 8 ml of phenyl isocyanate in 5 ml methylene chloride was stirred at room temperature for 72 hours. The mixture was diluted with ether and filtered. The ether solution was washed with water, dried over MgSO4 and evaporated to dryness. The crude residue was dissolved in acetonitrile, treated with charcoal and crystallized by addition of ether, m.p. 170°-172° C.

後処理

  1. filtrationfiltered
  2. washThe ether solution was washed with water
  3. dry with materialdried over MgSO4
  4. customevaporated to dryness
  5. dissolutionThe crude residue was dissolved in acetonitrile
  6. additiontreated with charcoal
  7. customcrystallized by addition of ether, m.p. 170°-172° C.

出典と根拠

ORDレコード
ord-4e4353bd8f7547899d389454002556e5
出典データセット
uspto-grants-1989_06
特許番号
US04839367

関連ノート

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