Ammonia → 1-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 1904789ノート

反応式

HRID 1904789 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([OH:16])=O)[CH2:10][CH:9]2[C:11](O)=[O:12])=[CH:4][CH:3]=1.[NH3:17]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:10][CH:9]2[C:11](=[O:12])[NH:17][C:14]3=[O:16])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 200380431-(4-Aminophenyl)-1,2-cyclopropanedicarboxylic acid

生成物 1

HCID 140689341-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

実験手順

In a glass bomb tube, 2.3 g of 1-(4-aminophenyl)-1,2-cyclopropanedicarboxylic acid are stirred in 80 ml of approx. 1N methanolic ammonia solution for 7 days at 100° C. The reaction mixture is evaporated to dryness and the residue is chromatographed over silica gel with hexane/ethyl acetate (4:6). Recrystallisation from ethanol affords white crystals of the title compound, which is identical with the title compound of Example 1.

後処理

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue is chromatographed over silica gel with hexane/ethyl acetate (4:6)
  3. customRecrystallisation from ethanol

出典と根拠

ORDレコード
ord-6909bc20c31c4a9f8a89c4819f518c19
出典データセット
uspto-grants-1989_06
特許番号
US04839379

反応ノート

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