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Pyridine → 5'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)- | HCID 78779 | — |
| 反応物 | 2-(2,4-Bis(1,1-dimethylpropyl)phenoxy)butyryl chloride | HCID 170393 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide | HCID 571108 | — |
反応手順
In 100 of ethyl acetate was dissolved 15 g (57×10-3 mole) of 2-benzamido-4-chloro-5-aminophenol, and then 21 g of 2-(2,4-di-t-amylphenoxy)butanoic acid chloride and 5 g of pyridine were added thereto and the mixture was stirred at room temperature for 3 hours. After the reaction, a solvent was distilled off, and the residue was separated and purified through column chromatography and recrystallized from n-hexane to obtain the title compound. Yield: 14.1 g, FD-Mass: 564, melting point: 190° to 191° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04840883 |
| 出典データセット | uspto-grants-1989_06 |
| ORD ID | ord-3f3b9b169a564527b7c42f85df29503a |
| 出典メモ | uspto-grants-1989_06 |