3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole → CH-13584

HRID 1904904ノート

反応式

HRID 1904904 の反応式
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[Na].Cl[CH2:15][C:16]1[N:20]=[C:19]([CH3:21])[O:18][N:17]=1>CN(C)C=O>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:15][C:16]3[N:20]=[C:19]([CH3:21])[O:18][N:17]=3)[C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12]

参加物

4

反応物 2

HCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 678245293-Methylxanthine sodium

生成物 1

HCID 163975CH-13584収率 71%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A mixture of 3.76 g of (20 millimoles) of 3-methylxanthine-sodium, 100 ml of dimethyl formamide and 2.60 g (19.6 millimoles) of 3-chloromethyl-5-methyl-1,2,4-oxadiazole is stirred at 100° C. for one hour and a half. The hot reaction mixture is filtered and to the filtrate 50 ml of methanol are added. Thus 3.65 g of 3,7-dihydro-3-methyl-7-([5-methyl-1,2,4-oxadiazole-3-yl]-methyl)-1H-purine-2,6-dione are obtained, m.p.: 262°-264° C. Yield: 69%.

後処理

  1. filtrationThe hot reaction mixture is filtered and to the filtrate 50 ml of methanol
  2. additionare added

出典と根拠

ORDレコード
ord-28789e223b2a40099c9f59ef8492b21e
出典データセット
uspto-grants-1989_06
特許番号
US04840949

反応ノート

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