Triphenylphosphine → 3-(5-Bromopentyl)-5-methylisoxazole

反応式

[Br:1]Br.C1(P([C:16]2[CH:21]=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:22][C:23]1[O:27][N:26]=[C:25]([CH2:28][CH2:29][CH2:30]Br)[CH:24]=1>>[Br:1][CH2:21][CH2:16][CH2:30][CH2:29][CH2:28][C:25]1[CH:24]=[C:23]([CH3:22])[O:27][N:26]=1

参加物

反応物 3

HCID 11776Triphenylphosphine

HCID 24408Bromine

HCID 133169753-(3-Bromopropyl)-5-methyl-1,2-oxazole

生成物 1

HCID 133169783-(5-Bromopentyl)-5-methylisoxazole収率 77%

実験手順

3-(5-Bromopentyl)-5-methylisoxazole [XXVII; R9 =CH3, Hal=Br] was prepared by reacting 3-(5-hydroxpentyl)-5-methylisoxazole with bromine and triphenylphosphine according to the procedure of part (f) above, and was obtained in 77% yield as an oil, b.p. 140°-150° C.(0.05 mm).