4,6-Dichloro-5-nitro-2-phenylpyrimidine → 4,6-Dichloro-2-phenylpyrimidin-5-amine

HRID 1905842ノート

反応式

HRID 1905842 の反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([Cl:11])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1>CCOCC.C([O-])(=O)C.[Ni]>[NH2:8][C:7]1[C:2]([Cl:1])=[N:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:5][C:6]=1[Cl:11]

参加物

4

反応物 1

HCID 1006444,6-Dichloro-5-nitro-2-phenylpyrimidine

生成物 1

HCID 7366734,6-Dichloro-2-phenylpyrimidin-5-amine収率 72.5%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 21226428Ether acetate溶媒

実験手順

27.0 g of 4,6-dichloro-5-nitro-2-phenylpyrimidine are hydrogenated in ether acetate at room temperature by treatment with Raney nickel. The catalyst is afterwards separated and the reaction solution is concentrated by evaporation. Crystallisation of the residue from petroleum ether then yields 17.4 g of 5-amino-4,6-dichloro-2-phenylpyrimidine, m.p. 143°-144° C. (compound No. 1).

後処理

  1. customThe catalyst is afterwards separated
  2. concentrationthe reaction solution is concentrated by evaporation
  3. customCrystallisation of the residue from petroleum ether

出典と根拠

ORDレコード
ord-0585826f0ec546e39554c0e3decd9b03
出典データセット
uspto-grants-1987_03
特許番号
US04648896

反応ノート

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