[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]([CH3:17])[C:15](=[O:18])[N:14]([CH3:19])[C:13](=[O:20])[CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[Cl:21]N1C(=O)CCC1=O>C(O)(=O)C>[Cl:21][C:12]1[C:13](=[O:20])[N:14]([CH3:19])[C:15](=[O:18])[N:16]([CH3:17])[C:11]=1[C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1To a solution of 6-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (2.0 g) in acetic acid (100 ml) was added N-chlorosuccinimide (0.97 g), and the mixture was stirred at 100° C. for 5 hours. After cooling, the reaction mixture was evaporated, and dissolved in chloroform, The solution was washed with aqueous sodium bicarbonate, and dried over magnesium sulfate. After removal of the solvent, resulting mass was crystallized from ethanol, to give 5-chloro-6-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1.79 g).
読み込み中…
