Ammonia → HCID 20144953、化合物
反応式
[CH3:1][NH:2][C:3]1[S:4][C:5]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[NH3:19]>>[C:8]([C:6]1[N:7]=[C:3]([NH:2][CH3:1])[S:4][C:5]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)(=[O:9])[NH2:19]参加物
3
実験手順
A solution of ethyl 2-methylamino-5-(4-pyridyl)-4-thiazolecarboxylate (2.36 g) in 26% methanolic ammonia (100 ml) was allowed to stand at ambient temperature for 5 days. The reaction mixture was evaporated in vacuo and the residue was washed with tetrahydrofuran to give 4-carbamoyl-2-methylamino-5-(4-pyridyl)thiazole (1.0 g). mp 212°-213° C. (from tetrahydrofuran-methanol).
後処理
- customThe reaction mixture was evaporated in vacuo
- washthe residue was washed with tetrahydrofuran
出典と根拠
- ORDレコード
- ord-158deac0235946bfa7cc961262284a17
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04649146
反応ノート
読み込み中…