Hydrochloric Acid → HCID 20144964、化合物
反応式
[CH3:1][N:2]([C:5]1[S:6][C:7]([C:11]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:20]=2)=[C:8]([CH3:10])[N:9]=1)C=O.Cl>C(O)C>[CH3:1][NH:2][C:5]1[S:6][C:7]([C:11]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:20]=2)=[C:8]([CH3:10])[N:9]=1参加物
4
実験手順
To a solution of 2-[2-(N-methylformamido)-4-methylthiazol-5-yl]-7-methylimidazo[1,2-a]pyridine (4.87 g) in ethanol (200 ml) was added 36% hydrochloric acid (2.6 ml) and refluxed for 1.5 hours. The reaction mixture was evaporated. The residue was dissolved in water, and the aqueous mixture was adjusted to pH 8 with saturated potassium carbonate. Extraction with chloroform, and evaporation afforded 2-(2-methylamino-4-methylthiazol-5-yl)-7-methyl-imidazo[1,2-a]pyridine (3.22 g). mp 220°-221° C.