2-Bromo-1-(thiophen-2-yl)ethan-1-one → HCID 12791243、化合物
反応式
Br.[Br:2][C:3]1[CH:4]=[N:5][C:6](=[O:9])[NH:7][CH:8]=1.Br[CH2:11][C:12]([C:14]1[S:15][CH:16]=[CH:17][CH:18]=1)=[O:13]>C(N(CC)CC)C.C(O)C>[Br:2][C:3]1[CH:4]=[N:5][C:6](=[O:9])[N:7]([CH2:11][C:12](=[O:13])[C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH:8]=1参加物
5
実験手順
A suspension of 5-bromopyrimidin-2-one hydrobromide (780 mg) and 2-bromoacetylthiophene (633 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for 11/2 hours. A solution formed within 10 minutes but a suspension subsequently resulted. This was chilled in ice, and the collected solid was crystallised from acetone to give the title pyrimidinone: yield 293 mg; m.p. 173°-175° C. dec; λmaxEtOH 259.5 nm (ε 9470), 287 nm (ε 6830), 332 nm (ε 2780).
後処理
- customA solution formed within 10 minutes
- customa suspension subsequently resulted
- temperatureThis was chilled in ice
- customthe collected solid was crystallised from acetone
出典と根拠
- ORDレコード
- ord-b40156b582e4475e90be585199500c68
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04650800
反応ノート
読み込み中…