Methylamine → N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

HRID 1906270ノート

反応式

HRID 1906270 の反応式
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8](OCC)=[O:9])[C:3]1=[O:13].[CH3:14][NH2:15]>O>[CH3:14][NH:15][C:8](=[O:9])[CH2:7][N:4]1[CH2:5][CH2:6][CH:2]([OH:1])[C:3]1=[O:13]

参加物

4

反応物 2

HCID 6329MethylamineHCID 13385945ethyl (R/S)-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetate

生成物 1

HCID 19817645N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.0 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate is treated with 10 ml of a 40% solution of methylamine in water. After stirring at room temperature for 1 hour, the mixture is evaporated. The residue is shaken five times with acetonitrile in order to remove the water, whereupon in each case it is again evaporated. The residue is treated with diethyl ether. By filtration there is isolated N-methyl-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide of melting point 129°-130.5°.

後処理

  1. customthe mixture is evaporated
  2. stirringThe residue is shaken five times with acetonitrile in order
  3. customto remove the water, whereupon in each case it
  4. customis again evaporated
  5. additionThe residue is treated with diethyl ether
  6. filtrationBy filtration

出典と根拠

ORDレコード
ord-4dfb110d5c6443be9bd9fc3d1ebc9b9d
出典データセット
uspto-grants-1987_03
特許番号
US04650878

反応ノート

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