Triethylamine → Methanesulfonamide, N-(1-cyano-1-methylethyl)-
反応式
[NH2:1][C:2]([CH3:6])([CH3:5])[C:3]#[N:4].C(N(CC)CC)C.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>C(Cl)Cl>[CH3:5][C:2]([NH:1][S:15]([CH3:14])(=[O:17])=[O:16])([CH3:6])[C:3]#[N:4]参加物
5
実験手順
To a stirred mixture of 8.4 g (0.1 mole) 2-amino-2-methylpropionitrile (the product of Example 1), and 10.1 g (0.1 mole) triethylamine in 125 ml methylene chloride, 11.5 g (0.1 mole) methanesulfonyl chloride in 25 ml methylene chloride were added dropwise over about 20 minutes in an exothermic addition reaction. The reaction mixture was stirred 15 minutes, then washed once with 100 ml water, washed twice with 50 ml water, dried over magnesium sulfate, and stripped to give 8.9 g of a brown oil.
後処理
- additionwere added dropwise over about 20 minutes in an exothermic addition reaction
- washwashed once with 100 ml water
- washwashed twice with 50 ml water
- dry with materialdried over magnesium sulfate
出典と根拠
- ORDレコード
- ord-fb29df81730041f88f1e009e792593bd
- 出典データセット
- uspto-grants-1987_03
- 特許番号
- US04652556
反応ノート
読み込み中…