Triethylamine → HCID 13799782、化合物

HRID 1906394ノート

反応式

HRID 1906394 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH2:9][C:10]([CH3:14])([CH3:13])[C:11]#[N:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:13][C:10]([NH:9][S:5]([CH2:4][CH2:3][CH2:2][Cl:1])(=[O:7])=[O:6])([CH3:14])[C:11]#[N:12]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 154103-Chloropropanesulphonyl chlorideHCID 880222-Amino-2-methylpropionitrile

生成物 1

HCID 13799782HCID 13799782、化合物収率 88.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred mixture of 9.90 g (0.05 mole) 3-chloropropane sulfonyl chloride and 4.71 g (0.056 mole) 2-amino-2-methyl-propionitrile in 100 ml methylene chloride at 0° C., 5.66 g (0.056 mole) triethylamine as a 10% solution in methylene chloride was added very slowly. The reaction mixture was allowed to stir overnight in the gradually melting ice bath. The reaction mixture was washed three times with 50 ml water. The organic layer was dried over calcium sulfate and evaporated to give 9.90 g of the above-identified product as a brown oil.

後処理

  1. washThe reaction mixture was washed three times with 50 ml water
  2. dry with materialThe organic layer was dried over calcium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-713009c3297d4ce6b18085c91542da66
出典データセット
uspto-grants-1987_03
特許番号
US04652556

反応ノート

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