関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | 2-(6-hydroxyhexyl)-2,3-dihydro-1H-isoindole-1,3-dione | HCID 12950219 | — |
| 生成物 | 6-Phthalimidohexyl acetoacetate | HCID 13752657 | 75% |
反応手順
A mixture of 22.1 g (0.09 mol) of N-(6-hydroxyhexyl) phthalimide and 10.2 g (0.08 mol) of ethyl acetoacetate was heated in an oil bath at 145° C. under nitrogen for 15 hours. After drying on high vacuum the residue was subjected to flash chromatography (silica gel, 7:3 petroleum ether/ether). The product was isolated as 12.9 g (75%) of a pale yellow oil b.p. 218°-226° C./0.15 mm. NMR: (CDCl3) w 1.5 (8H, m), 2.21 (3H, s), 3.35 (2H, s), 3.55 (2H, m), 3.99 (2H, t), 7.5 (4H, m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04652573 |
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| 出典データセット | uspto-grants-1987_03 |
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| ORD ID | ord-0c22014c440c4131a7fa27f07b346256 |
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| 出典メモ | uspto-grants-1987_03 |
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