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Potassium Hydroxide → Bamaluzole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2-Chlorobenzyl alcohol | HCID 28810 | — |
| 反応物 | 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine | HCID 948792 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Bamaluzole | HCID 3086242 | — |
反応手順
A mixture of 7.5 g of 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine, 7.1 g of 2-chlorobenzyl alcohol, 3.3 g of KOH and 100 ml of acetonitrile is refluxed for 7 hours. The solvent is removed and the residue is worked up in the customary manner (water/methylene chloride) to give 4-o-Chlorobenzyloxy-1-methyl-1H-imidazo(4,5-c)pyridine, m.p. 132°-135°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04654350 |
| 出典データセット | uspto-grants-1987_03 |
| ORD ID | ord-9c75251ce62041259494c3e9c8a4fb0a |
| 出典メモ | uspto-grants-1987_03 |