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4-Ethyl-3-thiosemicarbazide → N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Ethyl-3-thiosemicarbazide | HCID 1551780 | — |
| 反応物 | N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280298 | — |
| 生成物 | N-Methyl-N-[3-[3-(ethylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide | HCID 15595695 | 20.4% |
反応手順
A solution of 5.0 g N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 4.3 g 4-ethyl-3-thiosemicarbazide was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described in Example 70. Recrystalization of the product from dichloromethane-hexane afforded 1.2 g of yellow crystals, mp 198°-199° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04654343 |
| 出典データセット | uspto-grants-1987_03 |
| ORD ID | ord-ca3502e6e99e4428b064659657fa17bf |
| 出典メモ | uspto-grants-1987_03 |