Thiosemicarbazide → N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide

HRID 1906830

反応式

HRID 1906830 の反応式
[CH2:1]([N:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[N:15]=[N:16][C:17](Cl)=[CH:18][CH:19]=2)[CH:9]=1)[C:4](=[O:7])[CH2:5][CH3:6])[CH3:2].[NH2:21][NH:22][C:23]([NH2:25])=S>C(O)C>[CH2:1]([N:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][C:17]3[N:16]([C:23]([NH2:25])=[N:22][N:21]=3)[N:15]=2)[CH:9]=1)[C:4](=[O:7])[CH2:5][CH3:6])[CH3:2]

参加物

4

反応物 2

HCID 2723789ThiosemicarbazideHCID 14280299N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide

生成物 1

HCID 15595696N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide収率 44.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 5.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.2 g thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was treated and the product chromatographed as described for Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.4 g yellow crystals, mp 199°-200° C.

後処理

  1. additionThe mixture was treated
  2. customthe product chromatographed
  3. customRecrystalization of the product from dichloromethane-hexane

出典と根拠

ORDレコード
ord-2be52cf7f9bc4df9be7fe5307c8cc9e4
出典データセット
uspto-grants-1987_03
特許番号
US04654343

関連ノート

読み込み中…