Hydrochloric Acid → HCID 13826432、化合物

HRID 1906924ノート

反応式

HRID 1906924 の反応式
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1.Cl.S(Cl)([Cl:25])(=O)=O>C(Cl)Cl>[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]([Cl:25])[C:7](=[O:12])[C:6]=2[C:5]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:4]([CH3:20])[CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 13826430HCID 13826430、化合物

生成物 1

HCID 13826432HCID 13826432、化合物収率 95.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of ethyl 3-(4-chloro-2-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)propanoate (5.70 g, 20.3 mmoles) in CH2Cl2 (20 ml) was saturated with dry gaseous HCl and sulfuryl chloride (16.4 ml, 27.5 g, 203 mmoles) was added dropwise and stirred at room temperature for 2 hours. The solvent and excess sulfuryl chloride were evaporated in vacuo then chased with dry toluene two times to leave 6.40 g of title compound as a gum. Exact mass calculated for C16H17O3Cl (parent-HCl): 292.0866; Found: 292.0869

後処理

  1. additionwas added dropwise
  2. customThe solvent and excess sulfuryl chloride were evaporated in vacuo

出典と根拠

ORDレコード
ord-066b2796f69e479896e5f6b8d87d4e6b
出典データセット
uspto-grants-1987_03
特許番号
US04654363

反応ノート

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