Sodium Chloride → 3-(Methanesulfinyl)-1H-indole

HRID 1906932ノート

反応式

HRID 1906932 の反応式
S(OOS([O-])(=O)=O)([O-])(=O)=[O:2].[K+].[K+].[CH3:13][S:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1.[Cl-].[Na+]>O.CO>[CH3:13][S:14]([C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:2]

参加物

6

反応物 3

HCID 5234Sodium ChlorideHCID 24412Potassium PersulfateHCID 108882523-(methylthio)-1H-indole

生成物 1

HCID 130306043-(Methanesulfinyl)-1H-indole

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

Potassium persulfate (KHSO5, 55 g, 179 mmol) in water (300 ml) was slowly added to a solution of 3-methylthioindole (29.3 g, 179 mmol) in methanol (300 ml) cooled in a ice bath. One half hour after the addition was completed, water was added, the solution was saturated with sodium chloride and the product was extracted into chloroform. The extract was dried, evaporated in vacuo and the residue was crystallized from chloroform-ethyl acetate to give the title product.

後処理

  1. temperaturecooled in a ice bath
  2. additionOne half hour after the addition
  3. extractionthe product was extracted into chloroform
  4. customThe extract was dried
  5. customevaporated in vacuo
  6. customthe residue was crystallized from chloroform-ethyl acetate

出典と根拠

ORDレコード
ord-ab3cf6f5e7554f3a9cf5917d310e0113
出典データセット
uspto-grants-1987_03
特許番号
US04654360

反応ノート

読み込み中…