関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Methyldopa | HCID 38853 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | benzyl (S)-3-(3,4-dihydroxyphenyl)-2-methylalaninate | HCID 12439689 | 85% |
反応手順
In a manner similar to that described in Example I, 1.05 grams (0.005 mole) of α-methyldopa, 0.88 gram (0.010 mole) of lithium bromide, 0.5 gram of powdered 4A sieves, 0.98 gram (0.0057 mole) of benzyl bromide and 5.0 grams of N-methylpyrrolidinone were stirred for 65 hours at 25° C. At the end of this period, high pressure liquid chromatographic assay showed an 85 percent yield of the desired benzyl (S)-3-(3,4-dihydroxyphenyl)-2-methylalaninate product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04654433 |
|---|
| 出典データセット | uspto-grants-1987_03 |
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| ORD ID | ord-238cc03c63e6419c94662f644024e996 |
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| 出典メモ | uspto-grants-1987_03 |
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