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1-(2,6-Xylyl)piperazine → 1-[(6-Fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2,6-dimethylphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,6-Xylyl)piperazine | HCID 70538 | — |
| 反応物 | Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate | HCID 66917965 | — |
| 生成物 | 1-[(6-Fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2,6-dimethylphenyl)piperazine | HCID 11582272 | 65% |
反応手順
Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2,6-dimethylphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 65%). 1H NMR (300 MHz, CDCl3): δ 2.26 (s, 3H), 3.20 (s, 4H), 3.71 (s, 3H), 4.12-4.18 (m, 4H), 6.99-7.01 (m, 3H), 7.26-7.32 (m, 2H), 7.53-7.81 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08598173B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-e4ef2964a59e43029d5cb20fd2c2f638 |
| 出典メモ | uspto-grants-2013_12 |