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N-(2-Cyanophenyl)piperazine → 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-cyanophenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-Cyanophenyl)piperazine | HCID 2735875 | — |
| 反応物 | ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate | HCID 69243333 | — |
| 生成物 | 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-cyanophenyl)piperazine | HCID 69240955 | 88% |
反応手順
Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 88%). 1H NMR (200 MHz, CDCl3): δ 3.31 (s, 4H), 3.84 (s, 4H), 4.15 (s, 3H), 7.03-7.10 (m, 2H), 7.25-7.61 (m, 5H), 7.82 (dd, J=8.7 and 5.7 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08598173B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-2318c096c41b425d8ba013dcfb8d00f0 |
| 出典メモ | uspto-grants-2013_12 |