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1-(3,5-Dimethylphenyl)piperazine → 1-[(6,7-Dichloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethylphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3,5-Dimethylphenyl)piperazine | HCID 2758626 | — |
| 反応物 | Ethyl N-(6,7-dichloro-2-methoxyquinoxalin-3-yl)carbamate | HCID 69243293 | — |
| 生成物 | 1-[(6,7-Dichloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dimethylphenyl)piperazine | HCID 69243271 | 55% |
反応手順
Ethyl N-(6,7-dichloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(3,5-dimethylphenyl)piperazine were reacted by the same way with the example 176 to obtain the titled compound (yield, 55%). 1H NMR (300 MHz, CDCl3) δ 2.30 (s, 6H), 3.16-3.21 (m, 4H), 3.75-3.79 (m, 4H), 4.15 (s, 3H), 6.52-6.59 (m, 3H), 7.31 (br s, 1H), 7.85 (s, 1H), 7.92 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08598173B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-65d0596014b84ca98c7f3a10289c0085 |
| 出典メモ | uspto-grants-2013_12 |