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1-(m-Tolyl)piperazine → 1-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(m-Tolyl)piperazine | HCID 83111 | — |
| 反応物 | Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate | HCID 69244380 | — |
| 生成物 | 1-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine | HCID 69244359 | 56% |
反応手順
Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate and 1-(3-methylphenyl) piperazine were reacted by the same way with the example 190 to obtain the titled compound (yield, 56%) H NMR (300 MHz, CDCl3) δ 2.34 (s, 3H), 3.25-3.30 (m, 4H), 3.76-3.80 (m, 4H), 3.98 (s, 3H), 4.02 (s, 3H), 4.16 (s, 3H), 6.74-6.78 (m, 3H), 7.14-7.26 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08598173B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-3869dfe93f754597a8acf94f143d3dd6 |
| 出典メモ | uspto-grants-2013_12 |