2-(1-Ethylpropyl)-6-methoxyisonicotinic acid methyl ester → 2-(1-Ethylpropyl)-6-methoxyisonicotinic acid

HRID 1908740ノート

反応式

HRID 1908740 の反応式
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([CH:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=1>Cl>[CH2:13]([CH:12]([C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH3:11])[N:7]=1)[C:3]([OH:17])=[O:2])[CH2:15][CH3:16])[CH3:14]

参加物

3

反応物 1

HCID 670268752-(1-Ethylpropyl)-6-methoxyisonicotinic acid methyl ester

生成物 1

HCID 584181082-(1-Ethylpropyl)-6-methoxyisonicotinic acid収率 180.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 2-(1-ethyl-propyl)-6-methoxy-isonicotinic acid methyl ester (1.17 g, 4.97 mmol) in 25% aq. HCl (25 mL) is stirred at 70° C. for 16 h. The solvent is evaporated and the residue is dried under HV to give the title compound (2.00 g) as a yellow solid; LC-MS: tR=0.94 min; [M+1]+=224.01.

後処理

  1. customThe solvent is evaporated
  2. customthe residue is dried under HV

出典と根拠

ORDレコード
ord-1f3468b29ab24aeeb91f201ac69bc4d8
出典データセット
uspto-grants-2013_12
特許番号
US08598208B2

反応ノート

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