Hydrochloric Acid → 2-(Isopropylamino)-6-methylisonicotinic acid hydrochloride

HRID 1908743ノート

反応式

HRID 1908743 の反応式
C([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]([NH:12][CH:13]([CH3:15])[CH3:14])[CH:6]=1)C.[ClH:17]>>[ClH:17].[CH:13]([NH:12][C:7]1[CH:6]=[C:5]([CH:10]=[C:9]([CH3:11])[N:8]=1)[C:4]([OH:16])=[O:3])([CH3:15])[CH3:14]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 59504215Ethyl 2-(isopropylamino)-6-methylisonicotinate

生成物 1

HCID 670269742-(Isopropylamino)-6-methylisonicotinic acid hydrochloride

実験手順

A solution of 2-isopropylamino-6-methyl-isonicotinic acid ethyl ester (3.90 g, 17.5 mmol) in 32% aq. HCl (100 mL) is stirred at 70° C. for 5 h before it is cooled to rt and concentrated. The residue is dried under HV to give 2-isopropylamino-6-methyl-isonicotinic acid hydrochloride (4.20 g) as an orange resin; LC-MS: tR=0.52 min; [M+1]+=195.09.

後処理

  1. concentrationconcentrated
  2. customThe residue is dried under HV

出典と根拠

ORDレコード
ord-3d3c435b463740ea9e78b187b51aa0cc
出典データセット
uspto-grants-2013_12
特許番号
US08598208B2

反応ノート

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