6-Cyclopentyl-5-methyl-nicotinic acid isopropyl ester → 6-Cyclopentyl-5-methylnicotinic acid
反応式
C([O:4][C:5](=[O:18])[C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[N:8][CH:7]=1)(C)C>Cl>[CH:13]1([C:9]2[C:10]([CH3:12])=[CH:11][C:6]([C:5]([OH:18])=[O:4])=[CH:7][N:8]=2)[CH2:14][CH2:15][CH2:16][CH2:17]1参加物
3
実験手順
A solution of 6-cyclopentyl-5-methyl-nicotinic acid isopropyl ester (138 mmol, 558 μmol) in 25% aq. HCl (5 mL) is stirred at 65° C. for 24 h. The solvent is evaporated and the residue is dried under HV to give the title compound as a hydrochloride salt (163 mg) in form of a beige solid; LC-MS: tR=0.64 min; [M+1]+=206.50.
後処理
- customThe solvent is evaporated
- customthe residue is dried under HV
出典と根拠
- ORDレコード
- ord-8616d201a8c94805b75484ed0d08525a
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598208B2
反応ノート
読み込み中…