Hydrochloric Acid → 3-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]-piperidine
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][C:15]2[CH:25]=[CH:24][C:18]3[O:19][C:20]([F:23])([F:22])[O:21][C:17]=3[CH:16]=2)[CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl>[F:23][C:20]1([F:22])[O:19][C:18]2[CH:24]=[CH:25][C:15]([CH2:14][CH:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)=[CH:16][C:17]=2[O:21]1参加物
4
実験手順
To a solution of 3-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester (1.0 g, 2.8 mmol) in CH2Cl2 (11 mL) was added HCl (4 M in dioxane, 4.2 mL, 16.9 mmol). The reaction mixture was stirred at r.t. overnight and then concentrated to give 3-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-piperidine as the hydrochloride salt (791 mg, 96%). The crude product was used without further purification.