1,4-Dioxane hydrochloride → HCID 69001602、化合物
反応式
C([O:5][C:6](=[O:29])[CH2:7][N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)=[CH:17][CH:16]=1)(C)(C)C.Cl.O1CCOCC1>>[ClH:28].[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][CH2:13][C@H:9]3[CH2:10][CH2:11][CH2:12][N:8]3[CH2:7][C:6]([OH:29])=[O:5])=[CH:16][CH:17]=2)=[CH:23][CH:24]=1参加物
3
反応条件
- 温度
- 60 °C
実験手順
To the product from step 5 (0.60 g, 1.42 mmol) was added a 1:1 mixture of concentrated HCl/dioxane (28 mL). The resulting solution was stirred at 60° C. for 4 h. The solvent was removed in vacuo. The crude product was triturated with ether and dried under reduced pressure to afford the title compound (0.49 g, 52%) as a white solid.
後処理
- customThe solvent was removed in vacuo
- customThe crude product was triturated with ether
- custom