Hydrochloric Acid → (s)-Piperidin-2-ylmethanol hydrochloride
反応式
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:15][OH:16])=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[CH2:15][OH:16]参加物
4
実験手順
A 4M HCl solution in dioxane (30 mL) was added to (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (5.12 g, 23.78 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.43 g, 95%).
後処理
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-c66e70e7c9dc44f88641fa2abcb029e9
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598359B2
反応ノート
読み込み中…