関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl indole-7-carboxylate | HCID 676694 | — |
| 反応物 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 反応物 | (1-Phenylpiperidin-4-yl)methanol | HCID 17768191 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Methyl 1-((1-phenylpiperidin-4-yl)methyl)-1H-indole-7-carboxylate | HCID 58307013 | 13.9% |
反応手順
To a mixture of (1-phenylpiperidin-4-yl)methanol (958 mg), methyl 1H-indole-7-carboxylate (590 mg), and toluene (20 mL) was added (tributylphosphoranylidene)acetonitrile (1.0 g) at room temperature. The mixture was stirred at 100° C. for 1 day. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain methyl 1-[(1-phenylpiperidin-4-yl)methyl]-1H-indole-7-carboxylate (163 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08598355B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
|---|
| ORD ID | ord-a42d8d0904a242ed9ef58cd3e12324b9 |
|---|
| 出典メモ | uspto-grants-2013_12 |
|---|
