Ammonium Hydroxide → 5-Bromothieno[2,3-D]pyrimidin-4-amine

HRID 1909955ノート

反応式

HRID 1909955 の反応式
[Br:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.[OH-].[NH4+:13]>>[Br:1][C:2]1[C:10]2[C:9]([NH2:13])=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 454802995-Bromo-4-chlorothieno[2,3-d]pyrimidine

生成物 1

HCID 668238985-Bromothieno[2,3-D]pyrimidin-4-amine収率 86.3%

反応条件

温度
90 °C

実験手順

A suspension of 5-bromo-4-chlorothieno[2,3-d]pyrimidine (1 g, 4.01 mmol) in concentrated aqueous ammonium hydroxide (150 mL, 3852 mmol) was stirred overnight at 90° C. in a sealed vessel. The reaction was allowed to cool to room temperature and filtered. The white solid in the filter was air dried to afford 5-bromothieno[2,3-d]pyrimidin-4-amine (796 mg). LC/MS (ES) m/z=387.1 [M+H]+.

後処理

  1. temperatureto cool to room temperature
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-443a428a30dd4020bd5d2bdeacc9c33a
出典データセット
uspto-grants-2013_12
特許番号
US08598156B2

反応ノート

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