Triethylamine → (R)-alpha-[(2-t-Butoxycarbonylamino-2-methyl-1-oxopropyl)amino]-N-[[(2'-nitro)[1,1'-biphenyl]-4-yl]methyl]-1H-indole-3-propanamide

HRID 1910ノート

反応式

HRID 1910 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:28])([CH3:27])[C:10]([NH:12][C@H:13]([CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1)[C:14](O)=[O:15])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[N+:43]([O-:45])=[O:44])=[CH:33][CH:32]=1.C(N(CC)CC)C>C(Cl)Cl>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:28])([CH3:27])[C:10]([NH:12][C@H:13]([CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1)[C:14]([NH:29][CH2:30][C:31]1[CH:32]=[CH:33][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[N+:43]([O-:45])=[O:44])=[CH:35][CH:36]=1)=[O:15])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 15895387(R)-2-(2-((tert-Butoxycarbonyl)amino)-2-methylpropanamido)-3-(1H-indol-3-yl)propanoic acidHCID 196928864-Aminomethyl-2'-nitro-1,1'-biphenyl

生成物 1

HCID 22883359(R)-alpha-[(2-t-Butoxycarbonylamino-2-methyl-1-oxopropyl)amino]-N-[[(2'-nitro)[1,1'-biphenyl]-4-yl]methyl]-1H-indole-3-propanamide収率 56.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The acid (338 mg, 0.87 mmol) from Step D and 4-aminomethyl-2'-nitro-1,1'-biphenyl (200 mg, 0.87 mmol) and triethylamine (0.245 mL, 1.76 mmol) were dissolved in methylene chloride (8 mL) and stirred at room temperature. Benzotriazolyl-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (388 mg, 0.87 mmol) was added in a single portion. The reaction mixture was stirred together for 3.5 hours then the reaction was quenched by adding saturated aqueous sodium chloride (10 mL) and extracted with methylene chloride (3×20 mL). The combined extracts were dried over magnesium sulfate, filtered and evaporated under vacuum. The resulting thick gum was chromatographed on silica gel using ethyl acetate/hexanes (1:2 v/v) to give 297 mg (50%) of an orange semi-solid.

後処理

  1. stirringThe reaction mixture was stirred together for 3.5 hours
  2. customthe reaction was quenched
  3. additionby adding saturated aqueous sodium chloride (10 mL)
  4. extractionextracted with methylene chloride (3×20 mL)
  5. dry with materialThe combined extracts were dried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated under vacuum
  8. customThe resulting thick gum was chromatographed on silica gel

出典と根拠

ORDレコード
ord-27a0a2a0c29c44ca8129b0684f542de9
出典データセット
uspto-grants-1998_03
特許番号
US05726319

反応ノート

読み込み中…