Isoquinoline-3-carboxylic acid → HCID 178497277、化合物

HRID 1910211

反応式

HRID 1910211 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([OH:13])=O)[N:2]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:38][O:39][C:40]([C:42]1[C:50]2[N:49]=[C:48]([NH2:51])[NH:47][C:46]=2[CH:45]=[C:44]([C:52]2[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=2)[CH:43]=1)=[O:41]>>[CH3:38][O:39][C:40]([C:42]1[C:50]2[NH:49][C:48]([NH:51][C:11]([C:3]3[N:2]=[CH:1][C:10]4[C:5]([CH:4]=3)=[CH:6][CH:7]=[CH:8][CH:9]=4)=[O:13])=[N:47][C:46]=2[CH:45]=[C:44]([C:52]2[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=2)[CH:43]=1)=[O:41]

参加物

4

反応物 3

HCID 124656Isoquinoline-3-carboxylic acidHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 669405032-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester

生成物 1

HCID 178497277HCID 178497277、化合物収率 75%

実験手順

0.3 g (75%) of 2-[(isoquinoline-3-carbonyl)-amino]-6-pyridin-4-yl-3H-benzoimidazole-4-carboxylic acid methyl ester was synthesized from 0.16 g (0.09 mmol) of isoquinoline-3-carboxylic acid, 0.4 g (1 mmol) of HBTU, and 0.25 g (0.09 mmol) of the above synthesized 2-amino-6-pyridin-4-yl-1H-benzoimidazole-4-carboxylic acid methyl ester as described in general procedure A. LCMS: 424 (M+1)+.

出典と根拠

ORDレコード
ord-17dcdbc327b54f96bb211c12fe8e96c2
出典データセット
uspto-grants-2013_12
特許番号
US08598353B2

関連ノート

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