Bromine → 2-Amino-5-bromo-4-chlorobenzoic acid

HRID 1910229

反応式

HRID 1910229 の反応式
[Br:1]Br.[NH2:3][C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]>C(O)(=O)C>[NH2:3][C:4]1[CH:12]=[C:11]([Cl:13])[C:10]([Br:1])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

4

反応物 2

HCID 24408BromineHCID 666462-Amino-4-chlorobenzoic acid

生成物 1

HCID 196120502-Amino-5-bromo-4-chlorobenzoic acid収率 86%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

A solution of 2.65 mL (52.0 mmol) of bromine in 10 mL of acetic acid was added dropwise over 15 minutes to a solution of 8.89 g (52.0 mmol) of 2-amino-4-chloro-benzoic acid in 60 mL of acetic acid. The mixture was stirred at room temperature for 1 h and poured into 500 grams of ice. The solid was collected by filtration, washed with cold water and dried to produce 11.2 g (86%) of 2-amino-5-bromo-4-chloro-benzoic acid. LCMS: 251 (M+1)+.

後処理

  1. filtrationThe solid was collected by filtration
  2. washwashed with cold water
  3. customdried

出典と根拠

ORDレコード
ord-10d4a5404dcb499d99d66a2decc41c12
出典データセット
uspto-grants-2013_12
特許番号
US08598353B2

関連ノート

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