Methyl 2-(3-bromo-5-chlorophenyl)acetate → (5-Chloro-2'-{[ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

HRID 191025ノート

反応式

HRID 191025 の反応式
[CH3:35][O:36][C:37]([CH2:38][c:39]1[cH:40][c:41]([Br:46])[cH:42][c:43]([Cl:45])[cH:44]1)=[O:47].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][O:7][C:8]([N:9]([CH2:10][c:11]2[c:12]([B:21]3[O:22][C:23]([CH3:24])([CH3:25])[C:26]([CH3:27])([CH3:28])[O:29]3)[cH:13][cH:14][c:15]([C:17]([F:18])([F:19])[F:20])[cH:16]2)[CH2:30][CH3:31])=[O:32])[cH:33][cH:34]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][O:7][C:8]([N:9]([CH2:10][c:11]2[c:12](-[c:41]3[cH:40][c:39]([CH2:38][C:37]([O:36][CH3:35])=[O:47])[cH:44][c:43]([Cl:45])[cH:42]3)[cH:13][cH:14][c:15]([C:17]([F:18])([F:19])[F:20])[cH:16]2)[CH2:30][CH3:31])=[O:32])[cH:33][cH:34]1

参加物

3

反応物 2

HCID 58149292Methyl 2-(3-bromo-5-chlorophenyl)acetateHCID 66607601Ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid 4-fluoro-benzyl ester

生成物 1

HCID 66607076(5-Chloro-2'-{[ethyl-(4-fluoro-benzyloxycarbonyl)-amino]-methyl}-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

出典と根拠

ORDレコード
ord-095a272cfefd4507927348323dea2bf3
出典データセット
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

反応ノート

読み込み中…