Hydrochloric Acid → 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

HRID 1910392ノート

反応式

HRID 1910392 の反応式
[CH3:1][O:2][C:3]1([C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:22]>CCOC(C)=O.O>[ClH:22].[ClH:22].[CH3:1][O:2][C:3]1([C:16]2[N:17]([CH3:21])[CH:18]=[CH:19][N:20]=2)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 68570558tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

生成物 1

HCID 685712034-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (182 mg) in EtOAc (0.7 ml) and water (0.09 ml) was added 4N hydrogen chloride in EtOAc (0.7 ml) and the mixture was stirred at room temperature for 2 hours. Solvent was removed in vacuo to give 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride (122 mg) as a colorless powder. The obtained crude product was used in next reaction without further purification.

後処理

  1. customSolvent was removed in vacuo

出典と根拠

ORDレコード
ord-7bc64af39f604b6d96b2599468b9f6b9
出典データセット
uspto-grants-2013_12
特許番号
US08603975B2

反応ノート

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