Hydrochloric Acid → 4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

HRID 1910395ノート

反応式

HRID 1910395 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1.[ClH:20]>CCOC(C)=O>[ClH:20].[ClH:20].[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 23084145Tert-butyl 4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

生成物 1

HCID 685712954-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of tert-butyl 4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (132 mg) in EtOAc (1.3 ml) was added 4N hydrogen chloride in EtOAc (1.3 ml) and the mixture was stirred at room temperature for 2 hours. Solvent was removed in vacuo to give 4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride (108 mg) as a colorless powder. The obtained crude product was used in next reaction without further purification.

後処理

  1. customSolvent was removed in vacuo

出典と根拠

ORDレコード
ord-3866ff2a5a974e58b6f524dc76d4c426
出典データセット
uspto-grants-2013_12
特許番号
US08603975B2

反応ノート

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