Hydrochloric Acid → 4,6-Dimethyl-2(1H)-pyrimidinone hydrochloride

HRID 1910805ノート

反応式

HRID 1910805 の反応式
[C:1]([CH2:4][C:5](=O)[CH3:6])(=O)[CH3:2].[NH2:8][C:9]([NH2:11])=[O:10].[ClH:12]>C(O)C>[ClH:12].[CH3:2][C:1]1[CH:4]=[C:5]([CH3:6])[NH:11][C:9](=[O:10])[N:8]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 31261Acetylacetone

生成物 1

HCID 123431664,6-Dimethyl-2(1H)-pyrimidinone hydrochloride収率 55%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

To a mixture of acetyl acetone (4.0 g, 40.0 mmol) and urea (2.0 g, 33.3 mmol) in ethanol (40 mL) was added concentrated HCl (10 mL) and stirred at reflux for 3 h. The reaction mixture was cooled to 0° C. and filtered; the colourless solid was washed thoroughly with ice cold ethanol then ether and dried under vacuum to afford 4,6-dimethyl-1H-pyrimidin-2-one hydrochloride (3.5 g, 55%) as a solid.

後処理

  1. temperatureat reflux for 3 h
  2. filtrationfiltered
  3. washthe colourless solid was washed thoroughly with ice cold ethanol
  4. dry with materialether and dried under vacuum

出典と根拠

ORDレコード
ord-491904216b374f63a45fd8b8a8d40266
出典データセット
uspto-grants-2013_12
特許番号
US08604029B2

反応ノート

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