Hydrochloric Acid → HCID 12639347、化合物
反応式
[ClH:1].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]#[N:13])=[CH:7][CH:6]=1)([O-:4])=[O:3].[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12](=[NH:13])[O:16][CH2:14][CH3:15])=[CH:9][CH:10]=1)([O-:4])=[O:3]参加物
4
実験手順
Hydrogen chloride gas was passed through a solution of 4-nitrophenyl acetonitrile (5.0 g, 30.8 mmol) in ethanol (400 mL) until saturation, keeping the temperature between 0-5° C. The solvent was removed under reduced pressure at 15° C. to give a residue which on trituration with diethyl ether gave a solid. The solid was filtered under a nitrogen atmosphere and washed thoroughly with diethyl ether. Drying under vacuum afforded ethyl 2-(4-nitrophenyl)-acetimidate hydrochloride (3.5 g, 47%) which was hygroscopic in nature.
後処理
- custombetween 0-5° C
- customThe solvent was removed under reduced pressure at 15° C.
- customto give a residue which on trituration with diethyl ether
- customgave a solid
- filtrationThe solid was filtered under a nitrogen atmosphere
- washwashed thoroughly with diethyl ether
- customDrying under vacuum
出典と根拠
- ORDレコード
- ord-1c2b43cada934eb39f6cde83fcd75ada
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08604029B2
反応ノート
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