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Tetrahydro-2-furoic acid, (+)- → ((R)-3-{2-[4-(4-CHLORO-PHENYL)-PIPERAZIN-1-YL]-5-OXO-6,7-DIHYDRO-5H-5lambda4-THIENO[3,2-D]PYRIMIDIN-4-YLAMINO}-PYRROLIDIN-1-YL)-(R)-TETRAHYDRO-FURAN-2-YL-METHANONE
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydro-2-furoic acid, (+)- | HCID 2734707 | — |
| 反応物 | {2-[4-(4-chloro-phenyl)-piperazin-1-yl]-5-oxo-6,7-dihydro-5H-5lambda4-thieno[3,2-d]pyrimidin-4-yl}-(R)-pyrrolidin-3-yl-amine | HCID 59708374 | — |
| 生成物 | ((R)-3-{2-[4-(4-CHLORO-PHENYL)-PIPERAZIN-1-YL]-5-OXO-6,7-DIHYDRO-5H-5lambda4-THIENO[3,2-D]PYRIMIDIN-4-YLAMINO}-PYRROLIDIN-1-YL)-(R)-TETRAHYDRO-FURAN-2-YL-METHANONE | HCID 59708375 | — |
反応手順
Starting from {2-[4-(4-chloro-phenyl)-piperazin-1-yl]-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-yl}-(R)-pyrrolidin-3-yl-amine Diastereomer 1 (Example 171) (see scheme 3, 3.22) and (R)-(+)-tetrahydrofuran-2-carboxylic acid, Example 196 is prepared as described in Example 231 (see scheme 7). The product is purified by preparative HPLC (method B). Analytical HPLC-MS (method D): RT=1.18 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08604039B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-eca2c9814a764be9811dade2f8a84f1f |
| 出典メモ | uspto-grants-2013_12 |