関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 1-Chloroethyl chloroformate | HCID 521305 | — |
| 反応物 | 1-[4-(1-Benzhydryl-azetidin-3-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone | HCID 59625975 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 59625678 | HCID 59625678 | — |
反応手順
To a solution of compound 1f (2.11 g, 5.23 mmol) in CH2Cl2 (60 mL) was added 1-chloroethyl chloroformate (2.0 mL, 18.35 mmol) at 0° C. under N2. The mixture was stirred at 0° C. for 90 min and then MeOH (4 mL) was added. The mixture was refluxed for 1 h. Upon cooling, Et2O (50 mL) was added to the mixture. The resulting solid was collected by filtration and dried. The crude compound 1g was used in the next reaction without further purification. MS m/z (M+H+) 238.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08604017B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
|---|
| ORD ID | ord-e527049969ac4bbb9818c629d2bcc86d |
|---|
| 出典メモ | uspto-grants-2013_12 |
|---|
