Cyanogen Bromide → (S)-4-(2-phenyl-propyl)-4,5-dihydro-oxazol-2-ylamine

反応式

[NH2:1][C@@H:2]([CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[CH2:3][OH:4].[N:14]#[C:15]Br>>[C:8]1([CH:6]([CH3:7])[CH2:5][C@H:2]2[CH2:3][O:4][C:15]([NH2:14])=[N:1]2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

参加物

反応物 2

HCID 10476Cyanogen Bromide

HCID 68709718(S)-2-amino-4-phenyl-pentan-1-ol

生成物 1

HCID 59323620(S)-4-(2-phenyl-propyl)-4,5-dihydro-oxazol-2-ylamine

実験手順

In analogy to example 1b (S)-2-amino-4-phenyl-pentan-1-ol was reacted with cyanogen bromide to give (S)-4-(2-phenyl-propyl)-4,5-dihydro-oxazol-2-ylamine. Off-white waxy solid.

出典と根拠

ORDレコード: ord-29b2be5a3e5240098e2468fcaebcd4a9
出典データセット: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08604061B2

反応ノート

読み込み中…