Phosphorus oxychloride → 2-Chloro-8-(trifluoromethyl)quinoline
反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[NH:11][C:10](=O)[CH:9]=[CH:8]2.O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:10]1[CH:9]=[CH:8][C:7]2[C:12](=[C:3]([C:2]([F:15])([F:14])[F:1])[CH:4]=[CH:5][CH:6]=2)[N:11]=1参加物
3
実験手順
8-Trifluoromethyl-1H-quinolin-2-one (8.35 g, 39.2 mmol) was taken in a 25 mL RB POCl3 (10 mL) was added, and then refluxed for 1 h. The excess POCl3 was distilled off and ice was added to the reaction mixture. This was stirred for 15 min, the precipitate was filtered off and then dried under vacuum to afford the title compound (3 g, yield: 33%).
後処理
- additionwas added
- temperaturerefluxed for 1 h
- distillationThe excess POCl3 was distilled off
- additionice was added to the reaction mixture
- filtrationthe precipitate was filtered off
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-ced68df90c104877ac009b731c0b2942
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08604055B2
反応ノート
読み込み中…