Methylamine → 1269615-30-6

HRID 1911844ノート

反応式

HRID 1911844 の反応式
Cl[CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1

参加物

3

反応物 2

HCID 6329MethylamineHCID 122050815-chloromethyl-2-methyl-2H-tetrazole

生成物 1

HCID 670586961269615-30-6

反応条件

温度
45 °C

実験手順

To 5-(chloromethyl)-2-methyl-2H-tetrazole (136.8 mg, 1.032 mmol), was added methylamine (4.00 mL of 2M solution in THF, 8.00 mmol). This was stirred for 16 hours at 45° C. A white precipitate formed in the reaction and it was allowed to continue stirring for another 24 hours at room temperature before being concentrated in vacuo and successively azeotroped with THF, triethylamine, methanol, and then DCM. 1H NMR (600 MHz, CDCl3) δ 2.23 (s, 3H), 3.80 (s, 2H), 4.29 (s, 3H).

後処理

  1. customA white precipitate formed in the reaction and it
  2. stirringto continue stirring for another 24 hours at room temperature
  3. concentrationbefore being concentrated in vacuo
  4. customsuccessively azeotroped with THF, triethylamine, methanol

出典と根拠

ORDレコード
ord-0bcd22bebf4d40928a69a85fd30ac9f7
出典データセット
uspto-grants-2013_12
特許番号
US08604038B2

反応ノート

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